Does Psyllium Interfere With Cholesterol Medication?

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Should you be concerned if you are taking Psyllium while taking Cholesterol related medication?  No, there is no medical evidence which shows that Psyllium interferes with cholesterol lowering medication.

Psyllium, also referred to as ‘ispaghula’ (or isphagula), is derived from the husks of the seeds of Plantago ovata. Psyllium contains a high level of soluble dietary fiber, and is the chief ingredient in many commonly used bulk laxatives, including products such as Metamucil and Serutan.

Role Of Fiber

Fiber has two types: soluble and insoluble. Insoluble fiber enters and exits the body virtually unchanged, because it does not break itself or anything else down. Soluble fiber, on the other hand, absorbs a bunch of toxins and water from your intestines and drags them out of your body. Now there are some drawbacks to this absorption power of soluble fiber. Along with the harmful materials, soluble fiber in psyllium also absorbs a number of stuff, such as medication for other conditions.

Taking normal psyllium or any medicine that contains psyllium interferes with medicines such as anticoagulants, antidepressants, anti-gout agents, anti-inflammatory agents, diuretics, salicylates, tetracyclines, nitrofurantoin, insulin, lithium (Lithobid, Eskalith), and digoxin (Lanoxin). These medicines treat a wide array of conditions.

Compared to other conditions, high cholesterol medications easily adjust with psyllium. Cholesterol-lowering drugs include:

Cholesterol Lowering Drugs

Statins– Statins block the production of cholesterol in the liver itself. They lower LDL, the “bad” cholesterol, and triglycerides, and have a mild effect in raising HDL, the “good” cholesterol. These drugs are the first line of treatment for most people with high cholesterol. Statins have been shown in multiple research studies to reduce the risk of cardiovascular events like heart attacks and death from heart disease. Side effects can include intestinal problems, liver damage, and muscle inflammation.

Niacin– Nicotinic acid or Niacin is a B-complex vitamin. It’s found in food, but is also available at high doses by prescription. It lowers LDL cholesterol and raises HDL cholesterol. However, research has not shown that adding nicotinic acid to statin therapy is associated with a lower risk of heart disease.

Bile-acid Resins– These drugs work inside the intestine, where they bind to bile from the liver and prevent it from being reabsorbed into the circulatory system. Bile is made largely from cholesterol, so these drugs work by depleting the body’s supply of cholesterol.

Fibric Acid Derivatives– Fibrates or fibric acid derivatives reduce the production of triglycerides and can increase HDL cholesterol.

Psyllium Flavors

Psyllium is available in the following brands: Brands: Alramucil, Cilium, Fiberall, Genfiber , Hydrocil, Konsyl, Konsyl-D, Konsyl-Orange, Laxative Natural, Laxmar, Laxmar Orange, Laxmar Sugar Free, Maalox Daily Fiber Therapy, Metamucil, Metamucil Berry Burst Smooth Texture Sugar Free, Metamucil Orange Coarse Milled Original Texture, Metamucil Orange Smooth Texture, Metamucil Orange Smooth Texture Sugar Free, Metamucil Unflavored Coarse Milled Original Textur, Metamucil Unflavored Smooth Texture Sugar Free, Modane Bulk, Natural Fiber Therapy, Perdiem Fiber Powder, Reguloid, Serutan, V-Lax.


Experts believe that Psyllium works well with cholesterol lowering drugs. Taking them together has shown faster results in many people. However, consulting a doctor before adopting any kind of medication is advisable.

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