In an article earlier we had mentioned how fiber can help in reducing and curing gout problem. There has been another research result published in the article below which also suggests that high fiber diets can help in fighting gout.
This article suggests that the short chain fatty acids produced by friendly bacteria is one of the major reason why fiber rich diet can help fighting gout.
Main Cause Of Gout
Before we go further we would like to highlight the fact that there is lot of misconception around main reason for gout. Most websites keep on repeating each other that the main reason if consumption of sea food, meat or alcohol. But many people do not eat any of the items mentioned in the list and still frequently face painful gout attack.
Blood Sugar Factor
The main reason for gout is actually elevated blood glucose levels. The high blood glucose levels causes inflammation which is the reason for many diseases. Some of the health issues caused by inflammation are pre-diabetes or diabetes, high blood pressure, metabolic syndrome and obesity along with arthritis and gout.
When you continue to have diets which contain foods which raise the blood glucose levels fast such as white bread, white rise of foods made with refined flour your glucose levels will remain high constantly.
Once the glucose levels in the blood remain high for long period of time you start getting diseases and health conditions mentioned above. The the second problem happens. You start getting prescribed with drugs to suppress symptoms such as high blood pressure and these drugs can also cause conditions such as gout. For example Telmisartan drug for controlling blood pressure causes gout in some people.
What Latest Research Says
New research published in the Journal of Leukocyte Biology, shows that a high-fiber diet likely inhibits gout-related inflammation caused by monosodium urate (MSU) crystals. Specifically, researchers found that diets high in fiber trigger microorganisms in the gut to produce short chain fatty acids (SCFAs), which induce neutrophil apoptosis and the resolution of inflammation. These findings have important implications for the treatment of gout, and possibly for the treatment of arthritis.
“By understanding the way foods interact with living organisms, we may be able to create diets that help people with the disease, as well as their health overall,” said Mauro M. Teixeira, Ph.D., a researcher involved in the work from the Immunopharmacology Group in the Department of Biochemistry and Immunology at the Institute of Biological Sciences at the Federal University of Minas Gerais in Minas Gerais, Brazil.
Effect of High Fiber Diet and SCFA on Inflammation
To make their discovery, scientists used a high-fiber diet and treatment with SCFAs to prevent inflammation associated with the injection of MSU crystals in the knees of mice. Kinetic experiments showed that this caused neutrophil apoptosis and efferocytosis. Resolution of inflammation also was accompanied by enhancement of the production of anti-inflammatory cytokines in the knee joint, further preventing knee damage and dysfunction.
“We are seeing an explosion in our mechanistic understanding of how microbial communities in our intestines and elsewhere influence multiple aspects of immune and metabolic health,” said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology. “This work is an elegant example of how tuning of inflammatory circuits by linking diet to microbial products can have a profound effect on an inflammatory disease in the joints. Future work may allow such findings to be translated into practical treatments for gout and other diseases.”
The Journal of Leukocyte Biology publishes peer-reviewed manuscripts on original investigations focusing on the cellular and molecular biology of leukocytes and on the origins, the developmental biology, biochemistry and functions of granulocytes, lymphocytes, mononuclear phagocytes and other cells involved in host defense and inflammation.
Details: Angélica T. Vieira, Izabela Galvão, Laurence M. Macia, Érica M. Sernaglia, Marco Aurélio R. Vinolo, Cristiana C. Garcia, Luciana P. Tavares, Flávio A. Amaral, Lirlândia P. Sousa, Flaviano S. Martins, Charles R. Mackay, and Mauro M. Teixeira. Dietary fiber and the short-chain fatty acid acetate promote resolution of neutrophilic inflammation in a model of gout in mice. J. Leukoc. Biol. January 2017 101:275-284; doi:10.1189/jlb.3A1015-453RRR ; http://www.
How To Ensure That You Consume Sufficient Fiber
Taking sufficient fiber is not as hard as you think. This article can help you understand if you can get sufficient fiber. You can get fiber from from variety of foods such as nuts like walnut or almonds, vegetables such as spinach or broccoli or fruits such as apple or grape fruits. If you do not feel like taking vegetables often then you can take fiber supplements such as metamucil, benefiber or fiber smart.
If you eat more fiber rich foods and reduce processed foods and table sugar you will see that gout pain will gradually subside and you will develop more immunity to other inflammatory diseases as well.
Source – https://www.eurekalert.org/pub_releases/2017-01/foas-hfd010417.php
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